For instance, the low-molecular-weight inhibitor AX20017 blocks selectively the activity of the serine/threonine protein kinase PknG, a virulence factor of Mycobacterium tuberculosis, by interacting with a unique set of amino-acid side chains in the kinase domain that are not found in any human kinase.
Calcineurin B-like (CBL) proteins belong to a unique group of calcium sensors in plant that decode the Ca2+ signature by interacting with CBL-interacting protein kinases (CIPKs).
Although all the three pathways participate in ER stress-induced apoptosis and autophagy, PERK shows several unique characteristics by interacting with some specific downstream effectors.
As awesome as THC and CBD are, cannabis contains over 100 cannabinoids, and each offers its own unique contribution to our homeostasis, a state of healthy balance, by interacting with the body's natural endocannabinoid system.
Thus, each organism interacts with unique sets of environmental "drugs" or toxins.
In total, there are 538 unique genes that are interacting with 47,945 unique interactions.
In addition, SUB1 acts as a unique activator of p53 by directly interacting with p53, activating p53-mediated DNA binding, and inducing p53-responsive gene expression [19]– [19].
Different G-quadruplex folds can yield unique current signatures by interacting differently with the α-HL nanocavity.
͞ Individual Borrelia burgdorferi, shown in unique colors, interacting with the surface of endothelial cells, the cells that line blood vessels.
