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Moreover, MICOS establishes contact sites between inner and outer mitochondrial membranes by interacting with outer membrane protein complexes.
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During stroke associated apoptosis, cytosolic c-Jun N-terminal Kinases (JNKs) and Bcl-2 family proteins translocate towards mitochondria and promote cytochrome c release by interacting with the outer mitochondrion membrane associated proteins.
The mammalian HtrA (High Temperature Requirement) family of proteins show high homology to the bacterial chaperones DegS and DegP. 1, 2 DegS, a serine protease, acts as a stress sensor by interacting with unfolded outer membrane porins via its PDZ domain.
Another class of GTPase proteins including dynamin-related protein 1 (Drpromotemitochondrialdrial fission by interacting with its adaptor in the outer membrane such as fission protein 1 (Fis1) and mitochondrial fission factor [5]. Imbalanced mitochondrial dynamics are directly linked to many human diseases including neurodegenerative diseases, metabolic disorders, and cancer [6].
They contact the outer membrane by interacting with the TOB/SAM complex and the Ugo1-Fzo1 complex.
Colistimethate sodium is administered parenterally and exerts its effect by interacting with lipopolysaccharide (LPS) molecules, leading to outer membrane failure and disruption [ 6].
Most general anaesthetics work by interacting with ion channels.
Scientists think the nebula formed when stellar winds interacted with outer layers of hydrogen ejected by the star.
Instead of interacting with the outer crater, the methanesulfonamide group of KL001 is anchored at an outer vestibule of the FAD-binding pocket, where the FBXL3 C-terminal tail enters in the Skp1-FBXL3-CRY2 structure.
Moreover, as requested by one reviewer, we have shown that MIC60 maintains its ability to interact with the outer membrane protein SAMM50 when QIL1 expression is silenced.
Therefore, we hypothesized that Mieap may interact with mitochondrial outer-membrane proteins to target and enter the ROS-generating mitochondria.
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