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The second class includes the vinca alkaloids which inhibit tubulin assembly by interacting at the interface between α,β-dimers resulting in microtubule depolymerization.
The drug stabilizes covalent topoisomerase II-cleaved DNA complexes (i.e., cleavage complexes) by interacting at the enzyme DNA interface in a noncovalent manner.
They interfered viral attachment in early stage of replication cycle and suppressed the growth by interacting at the end of the infectious virus cycle (Keyaerts et al. 2007).
They are thus thought to function by interacting at the cell surface with sequence-specific DNA-binding proteins (DNA receptors) and/or components of the type 4 pilus system responsible for DNA uptake.
Recent reports from our group showed the ability of PEA to attenuate in vitro the A β-induced upregulation of a wide range of inflammatory mediators by interacting at the PPAR- α nuclear site.
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Re-expression of ARHI drives autophagy by interacting at several points in the development of autophagolysosomes.
In previous structural studies, we found that EspG occludes ARFGAP access to the GTP binding pocket of ARF1 by interacting at a distal site of the Switch I loop (Selyunin et al., 2011).
It also serves as an advocate for NTA and the fellows by interacting at a number of levels with administrators of NIEHS and NIH.
Interestingly, Hr was protective in cells treated with chemicals that induce apoptosis by interacting at different initial targets.
As reported in this article, healthy dietary molecules, calorie restriction, and exercise are able to direct cell metabolism toward catabolism and downregulate anabolism and inflammation by interacting at different levels with specific enzymes, nuclear receptors, and transcriptional factors.
Complex preterm phenotypes are determined by genetic, physiological and environmental factors interacting at the cellular, organ, systemic, and lifestyle levels.
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CEO of Professional Science Editing for Scientists @ prosciediting.com