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Not long ago, gene therapy seemed troubled by insurmountable difficulties.
"We stand here confronted," he wrote, quoting Pogo, "by insurmountable opportunities".
The first film colour systems were additive, but they were confronted by insurmountable limitations.
How each squad adapts to such changes will determine greatly whether 2016-17 will be a successful season or one defined by insurmountable obstacles.
Faced by insurmountable odds as the Carthaginians swept down the Italian peninsula during the Second Punic War, the Roman general Fabius Maximus simply retreated and retreated, wearing the opposition down by declining to engage with them at all.
Attempts at a comprehensive systematic review based on terms relating to toxicity were hampered by insurmountable difficulties in identifying relevant studies.
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He leads the runner-up David Reutimann by an insurmountable 552 points with two races to go.
In Puritan moral theology, the young, like the old, were sinners doomed by almost insurmountable odds to perdition.
But for many of us, the realization of this romantic desire is frustrated by one insurmountable limitation: the two-week vacation.
The Saudi Arabian foreign minister, Prince Saud al-Faisal, in his speech to the United Nations, said the plan was weighed down by the "insurmountable conditions of Israel".
Stripped to their core, most motion pictures deal with men confronted by seemingly insurmountable problems that must be solved in less than two hours of screen time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com