Sentence examples for by insufficient levels from inspiring English sources

Pre-eclampsia has also been characterised by insufficient levels of the vasodilator prostacyclin, and excessive production of thromboxane, a platelet-derived vasoconstrictor which stimulates platelet aggregation [ 47].

107 SMA is caused by insufficient levels of the protein SMN (survival motor neuron), a protein implicated in pre-mRNA splicing, mRNA transport, and axonal growth.

For instance, Vivanco et al. [ 3] indicated that therapeutic failure may be in part explained by insufficient levels of EGFR inhibition, and that targeting its inactive conformation may be a more effective strategy.

The postmaturity risk factor might be explained by insufficient levels of preventive anti-D Ig, after a single gift of 1000 iu (200 μg) in week 30 of pregnancy, in addition to the obvious immunogenic effect of prolonged exposure to fetal cells.

This finding suggests that amyloid plaque disrupts the transport of vitamin C into mitochondria via altered Glut1 and induce extracellular oxidative damage that cannot be blocked by insufficient levels of vitamin C. The structure of mitochondria features a double-membrane construction involving an outer and an inner membrane.

Spinal muscular atrophy is an autosomal recessive neuromuscular disorder that is caused by an insufficient level of survival motor neuron (SMN) protein.

Many energy scenario studies are at present characterized by an insufficient level of transparency.

This was done to artificially increase the level of genetic polymorphism, as preliminary tests indicated that each strain taken separately was characterized by an insufficient level of polymorphism.

DCs in the tumor microenvironment are usually found in an immature state, characterized by an insufficient level of expression of MHC class II complexes, co-stimulatory molecules such as CD80 and CD86 and IL-12.

Therefore, the majority of the nonsense-associated diseases are caused either by an insufficient level of the functional protein as a result of degradation of a PTC-containing mRNA, or by generation of a defective truncated protein from a PTC-containing mRNA that escaped the NMD surveillance [4], [8].

Thus, it is plausible that CREB overexpression leads to target gene upregulation and increased cell proliferation and survival that are not counteracted by the insufficient level of ICER expression.