Sentence examples for by inserting a mutation from inspiring English sources

They disrupted the function of DJ-1β by inserting a mutation into the middle of the gene.

RAG−/− mice were produced by inserting a targeted mutation on chromosome 2, resulting in a "non-leaky" severe combined immune deficiency[12].

pcDNA3-HA-UCH L1 C90S and H161D mutants were generated by inserting a specific mutation at the Cys 90 and H161 sites in wild-type pcDNA3-HA-UCH L1 plasmid with the use of the Quik-Change Site Directed Mutagenesis Kit following the manufacturer's instructions (Stratagene).

To exclude, the changes that were possibly caused by inserting a splice mutation and/or 'humanization' of exon 47 (6), we additionally compared the expression profiles of the 6-week-old MPI11Q/11Q KI mice (n = 3) with their WT littermates (n = 3).

To determine if any of these sites are functionally relevant, we created three early termination mutations by inserting a stop codon at various locations in the carboxy tail of mouse melanopsin.

Thus, this data supports numerous earlier reports in literature stating that Mn++ promotes mutation synthesis by inserting a higher ratio of incorrect to correct substrate.

Plasmids containing p.R776G mutation were constructed by inserting a BstXI fragment obtained by PCR amplification of an EGFR segment from a cDNA carrying this mutation into a BstXI-digested pcDNA3-EGFR vector.

The edr2-6 mutation was generated by inserting a 5.8 kb T-DNA fragment containing a right border (RB) and a left border (LB), the BAR gene, the NPTII gene and a fragment of an leucine-rich repeat gene driven by the 35S promoter.

The mutation R1827X was constructed by inserting a stop codon at position nt 6542 by SOE-PCR.

This problem has, in part, been solved by inserting a column for reporting the severity of individual mutations.

Next, they introduce a few mutations into its genetic code — perhaps by inserting a sequence from another enzyme with different desirable properties.