Sentence examples for by inhibition of extracellular from inspiring English sources
IL-1β suppressed isoproterenol-induced UCP1 mRNA expression in C3H10T1/2 adipocytes, and this effect was partially but significantly abrogated by inhibition of extracellular signal-regulated kinase (ERK).
T cell stimulation strongly induces glucose uptake and glycolysis, both of which are severely impaired by inhibition of extracellular signal-regulated kinase (ERK), whereas p38 inhibition had a much smaller effect.
Furthermore, radiation-induced INPP4B expression was blocked by inhibition of extracellular signal-regulated kinase (ERK).
We suggest that the HART model represents a very early stage of pre-hypertrophy in which VEGF signalling has not stabilized, the decrease in the NM population representing an initial mechanism to prevent fibrosis by inhibition of extracellular matrix.
Similarly, decreased MMP-2 and MMP-9 activity by inhibition of extracellular MMP inducer is correlated with higher perivascular cuff density and decreased EAE (experimental autoimmune encephalomyelitis) severity (Agrawal et al., 2012).
EGFR can be targeted either by inhibition of the extracellular ligand binding using monoclonal antibodies (mAbs), such as cetuximab, or by inhibition of the tyrosine kinase domain with a small molecule (TKIs), such as gefitinib, erlotinib and lapatinib.
However, this discrepancy indicates that the phenotypic changes induced by chronic inhibition of extracellular VEGF did not necessarily depend on compensatory pathways activated by VEGF family ligands, and can most likely be attributed to other pathway(s).
It is believed to have antibacterial property by the inhibition of extracellular enzymes synthesis and disruption of the cell wall structure resulting in lack of cytoplasm, cytoplasm granulation, cytoplasm hyperacidity, and depletion of intracellular ATP pool [19].
Furthermore, we show that the effects of miR-143 are mediated, at least in part by the inhibition of extracellular signal-regulated kinase-5 (ERK5) activity.
These authors reported that TNF- or IFN-γ-induced upregulation of HMGB1 mRNA expression is not affected in THP-1 cells by pharmacological inhibition of extracellular signal-regulated kinase (ERK) 1/ERK2 mitogen-activated protein kinase (MAPK)- or PKC (protein kinase C -dependent signaling but is inhibited by treating the C -dependentortmannin, an inhibitor of PI3K (phosignaling inositol-3-kinase).
The downregulation of VEGF-C and -D was caused by inhibition of p38 and extracellular signal-regulated kinase (ERK 1/2, respectively.
