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Furthermore, antibodies that can block the inhibitory activity of other antibodies have been described [28], [29], and antibodies may also act by inhibiting the processing of antigens required for erythrocyte invasion [29], [30].
Furthermore, αB-crystallin may confer stress resistance to cells by inhibiting the processing of the pro-apoptotic protein caspase-3 [ 15].
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These results show that the bioavailability of drugs, which are metabolic substrates of CYP1A2, CYP2C9, or CYP2C19, can be affected when these drugs are concomitantly administered with EEDS, causing potential adverse effects by elevating the plasma levels of cytotoxic drugs, or leading to therapeutic failure by inhibiting the metabolic processing of inactive prodrugs.
We have previously shown that abolishing CNX association by inhibiting the N-glycosylation processing or impairing tyrosinase tethering to the membrane results in a misfolded protein unable to exit the ER [20], [21], [ and 22].
Herpes simplex virus-1 (HSV-1) evades CD8+ T-cells by producing ICP47, which limits immune recognition of infected cells by inhibiting the transporter associated with antigen processing (TAP).
For example, microRNA-195-5p microRNA-195-5p microRNA-195-5prepress the glucose uptake and glycolysis processing by inhibiting the expression of glucose transporter 3 (GLUT3) and hexokinase 2 respectively.
Recently identified inhibitors of viral maturation act by disrupting the final stage of Gag processing, or by inhibiting the formation of a critical intermolecular CA CA interface in the mature capsid.
Boswellic acid inhibits prostaglandin synthesis by inhibiting the lipoxygenase pathway.
Importantly, Drosha cleavage was not affected by either mutation, clearly showing that the nucleotide changes mediated by editing are not themselves sufficient to inhibit the processing of mir-376a2.
This compound acts by inhibiting USP14, a proteasome-associated deubiquitinating enzyme that can inhibit the processing of ubiquitin protein complexes destined for degradation by the proteasome.
Absence of catalytic amino acids could inhibit the processing of target RNA by endonucleolytic cleavage in these proteins.
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