Sentence examples for by inhibiting the function from inspiring English sources
We have previously shown that PI3K/mTOR signaling inhibition sensitizes mesothelioma cells to drugs that are effluxed via ABCG2 transporter by inhibiting the function of ABCG2.
Acriflavine stops blood vessel growth by inhibiting the function of the protein hypoxia-inducible factor, or HIF-1, which was discovered by Semenza's team in 1992.
ROS damages DNA and promotes its mutation by inhibiting the function of DNA repair genes and increases the expression of DNA methyltransferases [116].
Brefeldin A (BFA) is a lactone antibiotic produced by fungal organisms which disturbs exocytosis by inhibiting the function of ADP-ribosylation factor-guanine-exchange factor.
Many TLR-inducible genes that are induced with delayed kinetics act as negative feedback regulators of TLR signalling by inhibiting the function of related isoforms [36].
Overall, these findings tentatively suggest that of the TKIs used in this study, imatinib and nilotinib are capable of reversing MRP7-mediated resistance by inhibiting the function of MRP7.
The indictment states that the 13 Russians and the three companies employing them defrauded the U.S. government by inhibiting the functions of the Federal Election Commission, which oversees campaign finance law, and the Department of Justice, which enforces the Foreign Agent Registration Act.
Most often, although not invariably, GSK-3s function as negatively acting kinases by inhibiting the functions of substrates at baseline.
Therefore, we hypothesized that the overexpression of the PF4 gene or p17-70 in MM cells would inhibit the growth of myeloma by inhibiting the functions of proangiogenic factors such as FGF2 and VEGF.
The FKBP12/rapamycin complex then binds the FRB domain in TOR proteins, thereby exerting its cell growth-inhibitory and cytotoxic effects by inhibiting the functions of TOR signaling to downstream targets such as S6K1 and 4E-BP1 [24], [24]– [24].
Extensive studies have revealed rapamycin's mechanism of action: upon entering the cells, rapamycin binds the intracellular receptor FKBP12, forming an inhibitory complex that binds the FRB domain in the C-terminus of TOR proteins, thereby exerting a cell growth-inhibitory and cytotoxic effect by inhibiting the functions of TOR signaling to downstream targets [10], [24]– [24].
