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However, it is not always clear whether these agents act directly as antioxidants to remove ROS, or whether they act indirectly by blocking ROS production by enzymes such as NADPH oxidase (NOX) enzymes, or by influencing the expression of cellular pro- and anti- oxidants.
For herbal extracts, several mechanisms of interference with the production or activity of eicosanoids have been described including the regulation of enzyme expression [8 10] and enzyme activity [11], but also by influencing the expression of eicosanoid receptors [8, 12].
By influencing the expression of novel resource-use phenotypes, maternal effects may play a largely underappreciated role in the origins of novelty.
The results of this study, both in vivo and in vitro, clearly demonstrate that all doses of DEHP strongly impair oocyte maturation and ovulation by influencing the expression of factors involved in these processes.
TGF-β signaling inhibits proliferation in multiple epithelial cell types by influencing the expression of cell cycle regulatory proteins to induce arrest prior to the restriction point in G1.
20 Sirtuin 6 has been found to suppress aerobic glycolysis by influencing the expression and function of HIF-1α.
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Interestingly, recent studies have demonstrated that a variety of miRNAs, acting as oncogenes or tumor suppressors, regulate survival and invasion by directly influencing the expression of MMPs [ 12].
Thus, our data suggest that the addition of growth media may potentially reduce chromosomal instability and improve IVF outcomes by positively influencing the expression of epigenetic regulators in human embryos.
In summary, our data demonstrate that the two novel FTY720 derivatives act as anti-inflammatory ultimately by influencing the gene expression via the cAMP and downstream transcription factor CRE pathway.
CNV can contribute to disease susceptibility by influencing the gene expression level [11].
Interferons are cytokines that can affect the recognition of tumour cells by the immune system by influencing the (re)expression of HLA molecules on the cell surface.
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