Radiation therapy may induce pathophysiological changes in all normal tissue or organs within the irradiated volume, which in some cases will lead to symptoms negatively affecting daily activities and quality of life.
It is possible that the generalization of the seizure discharge may induce other pathophysiological changes in the whole brain structure.
Proinflammatory cytokines play a pivotal role in the pathophysiology of sepsis, and overproduced cytokines enter the bloodstream causing hypercytokinemia, which induces various pathophysiological changes and eventually results in organ failure [ 10, 11].
Early hypothesis of AD pathology posits that 39 43 AA long misfolded amyloid beta (Aβ) peptide forms a fibrillar structure and induces pathophysiological response by destabilizing cellular ionic homeostasis.
NGOs are increasingly influencing business decisions, not by regulatory fiat, but by inducing changes in consumer behavior.
These observations suggest that the phenotype caused by loss of Sirt6 is dose-dependent and a threshold must be reached to induce pathophysiological alternations.
The obstruction of cerebral blood flow induces time-dependent pathophysiological changes in brain tissue, including tissue necrosis, and can cause death if the situation is not resolved quickly.
The present protocol did not include the treatment of hyperuricemia, since the UA-lowering drugs allopurinol, febuxostat and uricosuric agents have been well documented to prevent the pathophysiological changes induced by the oxonic acid feeding [ 4- 6, 10, 30, 44- 46].
COPD is a disease characterized by airflow limitation caused by severe pathophysiological changes including chronic bronchitis, small airway remodelling, mucus production and the development of emphysaema [ 2].
