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Furthermore, pathological changes to the lung epithelium may drastically influence the crosstalk between stem cells and their niche, which further contributes to disease progression by inducing abnormal changes in mesenchymal components, such as ASMC hyperplasia and fibroblast activation leading to excessive ECM deposition and fibrotic scarring.
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These findings suggest that LOXL2 expression in normal epithelial cells can induce abnormal changes that resemble oncogenic transformation and cancer progression, and that these effects are driven by LOXL2-mediated activation of ErbB2.
The insufficiency and exhaust of ATP was a potential toxic mechanism of erythrocyte caducity by inducing abnormal ion transport, energy metabolism suffocation, and declined erythrocyte deformability [46].
Loss of Huwe1 induced abnormal morphological changes of myotubes.
The unique property of prions is their ability to induce abnormal conformational changes in normal prion proteins.
This metabolic disturbance caused by fat infiltration could induce abnormal liver enzyme.
These findings suggest that PCBs/dioxins induce abnormal brain development by directly acting on TR.
NGOs are increasingly influencing business decisions, not by regulatory fiat, but by inducing changes in consumer behavior.
UBD deregulation may induce abnormal alterations in apoptosis, cell division or chromosome instability, which are associated with neoplastic change (Sarasin, 2003; Adler et al, 2009).
Genetic alterations may induce abnormal gene expression.
This response suggests that cells have finely tuned sensing mechanisms that counteract abnormal changes induced by stress-inducers.
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