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The immunotherapeutic fusion protein (MBP-C5a) developed targets C5a by inducing a polyclonal antibody response.
By inducing a polyclonal expansion of CD4+ cells mainly characterized by a naïve or central-memory phenotype [7], IL-2 greatly enhances the proliferation and function of T-lymphocytes and natural killer cells and promotes the production and release of other cytokines [8].
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Antigens derived from the eggs and adult worms are continuously drained to MLNs and induce a polyclonal B cell activation.
If so, these scFv should be able to induce a polyclonal anti-anti-Id response (Ab1′) when injected into mice.
This approach also has the potential to induce a polyclonal response against multiple epitopes, which may be relevant for improved efficacy.
Immunogenicity of modified HSA was probed by inducing polyclonal antibodies in rabbits.
This class of multi domain biotherapeutics (MDBs) is composed of the three major domains Fab, Fc, and a cytokine which may induce a complex polyclonal anti-drug antibody (ADA) response.
M. ovipneumoniae induced a strong in vitro polyclonal suppression of CD4+, CD8+, and B blood lymphocyte subsets.
A different hypothesis suggests that platinum salts could induce an oligo or polyclonal T-cells expansion.
Baird and coworkers reported that stimulation of IgE-bound FcεRI by polyclonal Abs against IgE induced a detergent-resistant association of these complexes with the cellular cytoskeleton [ 32].
In a polyclonal repertoire, an increase in Ag concentration may induce a stronger CD8+ T cell response by recruiting T cells with lower affinity for Ag, thereby yielding a different interpretation of the results.
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