Sentence examples for by inducing a mutation from inspiring English sources

They approached the problem by inducing a mutation in the comparable gene in the brewer's yeast, Saccharomyces cerevisiae.

Xsmad2-P445H was cloned by inducing a point mutation at amino acid 445 (CCT to CAT, Eppert et al., 1996) using the QuikChange II Site Directed Mutagenesis Kit (Agilent Technologies, Santa Clara, CA) using the following mutagenesis primers: forward 5′-GAGCTTCACCTGAATGGACACTTGCAGTGGTTGGACAAAG-3′ and reverse 5′-CTTTGTCCAACCACTGCAAGTGTCCATTCAGGTGAAGCTC-3′.

Our central conclusion is that large-scale vaccination programs have been responsible for a very large reduction in influenza severity in the last century, initially by inducing a few key mutations to superstrains A and then B and C, but most recently by driving a large-scale Lévy jump from C to new and remarkably compact, mild, and convergent superstrains D and D*.

Because HIF protects cells from irradiation therapy under hypoxic condition, we may hypothesize that IDH mutation, by inducing an inappropriate degradation of HIF, could make the mutated cell more vulnerable to RT.

Reverse genetics starts with the normal gene sequence (as obtained by genomics), induces a targeted mutation into the gene, then, by observing how the mutation changes phenotype, deduces the normal function of the gene.

Hybrid genes are candidate risk factors for human tumors by inducing mutation, translocation, inversion, or rearrangement of genes.

Among the physical factors, the most familiar factor is light, especially ultraviolet, which promotes risks of cancer generation by inducing gene mutations and disturbing glycolysis [25].

Moreover, an important set of host cell restriction factors, the apolipoprotein B editing complex (APOBEC) proteins, restrict retroviral replication by inducing G→A mutations during reverse transcription, and XMRV was found to be sensitive to human APOBEC3G.

The virus tends to limit the T-lymphocyte responses by inducing mutations in T lymphocyte epitopes to escape from a cellular immune defence system [ 67].

The amino-acid sequence of a protein, and hence its function, can be modified by inducing mutations in the nucleotide sequence of its gene.

It is assumed that direct DNA-reactive carcinogens initiate carcinogenesis by inducing mutations and have low-dose linear dose response curves, whereas carcinogens that operate through a nonmutagenic MOA may have nonlinear dose responses.