Stimulation by activin induces association of Dok-1 and Smad3 [ 22].
Inhibition of topoisomerase II activity mediated by etoposide induces DNA lesions activating ATR (Costanzo and Gautier, 2003; Costanzo et al, 2003).
Inhibition of autocrine SDF-1 α/CXCR4 signaling by AMD3100 induces cell adhesion in normal cervical cells (NC65 and NC66), suggesting that autocrine SDF-1 α/CXCR4 signaling positively regulates the loss of cell adhesion.
Activation of DPAGT1 expression by Wnt signaling induces canonical Wnt activity by controlling N-glycosylation of its upstream regulatory components.
The activation of EphB2 by ephrin-B1 induces association of EphB2 receptors with the NMDAR [ 90] and AMPARs [ 93] through PDZ domain containing proteins.
These data suggest that sTRAIL expression mediated by rAAV-TRE-TRAIL&rAAV-Tet-On induces tumor cell death by apoptosis, which is strictly regulated by Tet-On system.
To investigate the pathways by which boesenbergin A induces apoptosis, we performed a determination of apoptosis-related proteins using the Proteome Profiler Array (RayBio® Human Apoptosis Antibody Array Kit, RayBiotech, GA, USA), according to the manufacturer's instructions.
Etoposide induces DNA breaks by inhibition of topoisomerase II (topoII) [17], an enzyme that induces transient DSBs as part of its enzymatic mechanism [18], [19], [20], [21].
In gliomas, paracrine PDGF signaling induces neo-angiogenesis by directly stimulating proliferation of PDGFRβ-positive tumor endothelial cells [8], [35].
While BRCA1+ induces breast cancer by causing genome instability, most of the knowledge is known about somatic genome instability in breast cancer cells but not germline genome instability.
