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There may be residual confounding that is not captured, such as confounding by indication or indicator.
However, confounding by indication remains a major problem.
However, confounding by indication bias cannot be ruled out [48].
Confounding by indication or other confounding exist in most observational studies.
A multivariate analysis cannot deconstruct such confounding by indication [55]; only RCTs can [56].
These factors expose a limitation of our systematic review and the included studies: confounding by indication.
However, these associations may be affected by residual confounding by indication.
It is tempting to attribute this observation to bias by indication.
This will lead to confounding by indication.
However, confounding by indication can be important.
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We assessed whether confounding-by-indication might account for these results.
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