Sentence examples for by increasing the cellular from inspiring English sources
Accordingly, HeLa cells were treated with ammonium chloride (NH4Cl) at 20 hours post transfection for 4 hours, which will block lysosomal degradation by increasing the cellular pH and thereby inactivating protease activity within lysosomes (Fig. 5a; panel 2 35.
Collectively, these results are consistent with a model in which signaling pathways initiated by TGFbeta can stimulate CREB-dependent transcription by increasing the cellular concentration of c-Jun, which participates in activation of the CBP-containing transcription complex.
Thus, ATGL could influence PPAR activity by increasing the cellular concentration of both FAs and ROH.
Our results suggest that iAsIII enhanced the formation of BPDE DNA adducts by increasing the cellular uptake of BPDE.
The metabolic influx into the TCA cycle could be enhanced by increasing the cellular NAD and pyruvate levels.
TZDs can also activate AMPK by stimulating the release and expression of circulating adiponectin from adipose tissue [ 66, 67] or indirectly by increasing the cellular AMP/ATP ratio, possibly by a similar mechanism to biguanides [ 108].
In fact, cellular heterogeneity often plays a critical role in ensuring proper cellular response by mechanistically increasing the cellular response range to a constantly changing environment (Altschuler and Wu, 2010).
This type of genetic interaction often indicates a physical association; for example, the missense mutation in smc6-74 mimpairmpair binding to Brc1, which is a defect that might be suppressed by increasing the total cellular concentration of Brc1.
Converging evidence from pharmacological and molecular studies has led to the suggestion that inhibition of glycine transporter 1 (GlyT1) constitutes an effective means to boost N-methyl-d-aspartate receptor (NMDAR) activity by increasing the extra-cellular concentration of glycine in the vicinity of glutamatergic synapses.
Neoplastic infiltration of the bone marrow in MR images results in a replacement of the fatty converted marrow by neoplastic cells, thereby increasing the cellular content of the bone marrow, which results in a prolongation of T1- and T2-relaxation times and subsequent decreased T1-signal and increased T2-signal of the bone marrow.
The 2A-N32D suppressor mutation was not allele specific and, by increasing the rate of cellular apoptosis, affected a completely different pathway than the 2C-E253G Sin mutation.
