Sentence examples for by increasing its stability from inspiring English sources
It is known that DNA damage can induce p53 by increasing its stability (e.g., protein phosphorylation) and/or stimulating its translation.
Surfactant additives can enhance the emulsion stability through regulating the Zeta potential, and the surfactant pre-flush fluid can improve the injection efficiency of emulsified asphalt by increasing its stability.
Whereas, the reduction in voidage volume added strength to the bituminous concrete by increasing its stability and density, the reduction in VMA had no positive impact on the strength properties of the flexible road-surface.
It has also been documented that phosphorylation of the C-terminal tail of PTEN decreases the degradation of PTEN protein by increasing its stability [29].
Further examination of MC-26 cells in the present study suggests that gastrin prolongs the half-life of β-catenin by increasing its stability.
Since AR binding to androgen greatly increases its stability, androgen administration could increase the level of AR protein by increasing its stability.
Here, we identified obacunone as a novel activator of Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability.
Upon DNA damage, AATF is phosporylated by ATM and CHEK2, consequently increasing its stability and accumulation to the cell nucleus, but also enhancing p53 expression and G2-M arrest [ 10, 15].
Similar to bosentan, our latest paper demonstrated that imatinib reverses the decreased expression of Fli1 in SSc dermal fibroblasts by increasing its protein stability and without affecting its gene expression status [ 33], suggesting that imatinib is a potential disease-modifying drug for SSc patients.
In agreement with previous studies [23], we found that under basal conditions Nrf2 was localized in the nuclei and that activation by H2O2 increased its stability, ARE-driven activity and anti-oxidant gene expression.
This suggests that farnesylated proteins predominantly maintain a high level of ER expression within the whole cell (either by repressing the degradation of ER or by increasing its expression or stability), whereas geranylgeranylated proteins could only stimulate the nuclear expression of the ER.
