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For example, the addition of salt is known to modify the matrix of the sample by increasing ionic activity.
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The increased attachment by increasing ionic strength is due to the increasing van der Waals attractive forces.
These results suggest a salt masking effect where stable MutL-ssDNA contact(s) are either eliminated or substantially reduced by increasing ionic strength [20].
These electrostatic interactions can be screened by increasing ionic strength.
The boiling point elevation caused by elevated concentrations of dissolved salts is captured in the model through the lowering of the water-vapor pressure resulting from the decrease in water activity with increasing ionic strength [34].
In this approach, the complex is destabilized by adding organic solvent or increasing ionic strength of the sample solution.
Drug development based on AMPs is complicated by the fact that the antimicrobial activities of numerous naturally occurring AMPs are antagonised by physiological salt concentrations, which might reflect the increasing ionic strength under high salt conditions weakening the electrostatic charge interactions of AMPs with bacterial membranes (Tam et al. 2002).
However, in contrast to the matrix only, three distinct RNA binding activities were eluted under conditions of increasing ionic strength from the dengue 3'SL RNA column.
Under such conditions, electrostatic forces subject to electrostatic screening from increasing ionic strength are not expected to contribute to the observed activity.
Melting and hybridization steps are in principle also possible by tidal cycling [ 24] in combination with drying and increasing salt concentration, since increasing ionic strength also favors melting.
The effect of large size may sometimes be offset by an increased ionic charge, which tends to orient the water molecules and stabilize the dissolved ion.
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