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These results suggest that Wnt-induced PLD upregulation is required for β-catenin/TCF-4 transcriptional activation by increasing formation of the β-catenin/TCF-4 β-catenin/TCF-4 β-catenin/TCF-4
Interestingly, our data demonstrate that Wnt-induced PLDs upregulation promotes β-catenin/TCF transcriptional activity by increasing formation of the β-catenin/TCF-4 protein complex, and then enhances expression of TCF-4-dependent genes.
Thus, oxLDL-β2-GPI complexes may contribute to atherosclerosis by increasing formation of foam cells.
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The latter observation was explained by increased formation of oxidised LDL-specific immune complexes.
This is caused, at least in part, by increased formation of the endogenous nucleoside adenosine [ 3].
Paradoxically, the effect of hormesis may be mediated by increased formation of ROS, especially by the mitochondria believed to be the main source of ROS in the cell.
The alf3 mutation causes primary root growth arrest and death, followed by increased formation of lateral root primordia that fail to mature and subsequently die.
Next, we analyzed the effects of JAK inhibitors on TNF-induced osteoclastogenesis and discovered that both compounds augmented nuclear levels of NFATc1 and cJun, followed by increased formation of TRAP positive multinuclear cells.
The antiproliferative impact of TNF-α in human HSCs, the MFs of the liver, was previously described to be mediated by increased formation of nuclear factor-kappa-B (NF-κB) DNA-binding complexes [ 29].
As precursor concentrations increase, SOA prediction is complicated by the increasing formation of higher molecular weight products; peak oxalic acid concentrations occur later in the reaction sequence, and higher molecular weight products, including >C2 organic acids and oligomers form.
Wnt3a induced a spindle-like morphology in fibroblasts characterized by the increased formation of stress fibres.
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