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But previous research has found that hormone treatment can cause delays in diagnosis by increasing breast density, making tumors harder to see on mammograms.
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Furthermore, we will be able to assess whether mortality reduction by earlier detection differs with increasing breast density between screening with digital mammography or with additional MRI.
As there appears to be an approximately linear relationship between RR and breast density moving from 3% density to 15% density is associated with a RR of 1.79, and increasing breast density by 1.83% would equate with a RR of 1.12.
Animal protein intake may increase breast density by increasing circulating levels of insulin-like growth factor-1 [ 32, 33], which has been linked to higher breast density [ 34] and higher breast cancer risk [ 35- 37] among premenopausal women.
Conclusion: In postmenopausal women with low bone mass, raloxifene therapy for 12 months does not increase mammographic breast density, whereas continuous-combined hormone therapy substantially increases breast density in a significant number of women.
Hormone exposure, for example, increases breast density and also the risk of breast cancer.
Increased breast density is a strong surrogate for future breast cancer risk.
Also, the addition to progestin to estrogen in menopausal HRT increases breast density at mammography and increased breast density is a risk factor for breast cancer (Warren 2004).
A leading risk factor for breast carcinoma is increased breast density, which accounts for approximately 30% of breast cancers (1).
In this study, increased breast density appeared to contribute to the poor sensitivity of mammography.
The study has shown that, at this dose of Promensil, there is no evidence of any increase in radiological breast density in women who already have increased breast density, in spite of the well-documented evidence that HRT will increase breast density and tamoxifen will reduce breast density.
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