The acute diarrhea induced by radiotherapy includes increased stool frequency, increased degrees of hardness and volume of stool, severely watery stools, or a mixture of blood, serum, mucus, and other items.
This suggestion is supported by a recent single center, randomized, double-blind dose escalation study in 30 patients with CIC, which found that A3309 significantly accelerated colon transit measured by radio-opaque markers and increased stool frequency compared with placebo (16).
Patients could mention one or more than one drug to be associated with one ADE in the questionnaire, for example, increased stool frequency caused by metformin and tolbutamide.
CDCA has been found to have several beneficial effects in adults with IBS-C including acceleration of colonic transit, increased stool frequency, and loosening of stool consistency [83].
As determined by daily stool diaries, linaclotide shortened the time to first bowel movement (P = 0.013), increased stool frequency (P = 0.037), decreased stool consistency (P < 0.001), and improved ease of stool passage (P < 0.001).
Increased stool frequency was maintained over 8 weeks.
Increased stool frequency or loose bowel movements can be distressing for the child or parents/carers.
Prucalopride 0.5, 1, or 2 mg administered once daily proportionally increased stool frequency (P<0.05) and decreased the time to the first stool (P<0.001).
With milk consumption, one subject complained of feelings of bloating and having loose stools, while two subjects reported increased stool frequency or cramps.
