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This approach is superior to other approaches with respect to minimizing false positive finding due to population structure and cryptic relationships accompanied by increased statistical power [41].
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To generalize, we suggest that by increasing statistical power one is likely to detect and define robust differences in pattern recognition between any pair of individual PDZ domains.
Overall, the reported meta-analysis approach showed successful integration of heterogeneous data sets of limited size by increasing statistical power.
The present meta-regression analysis aims to shed light on this specific point, by increasing statistical power and enhancing the precision of estimates across multiple modest-size trials.
The databases also provide the added benefit of increased statistical power by facilitating pooling of data from multiple study populations.
One example of increased statistical power afforded by the network is presented in Table 2 for one of the secondary outcomes (diabetic retinopathy) that leverages genotyping already performed for one of the primary eMERGE phenotypes.
By borrowing strength across the gene set, there is potential for increased statistical power.
These could only be revealed by the increased statistical power of pooling data across subjects.
Based upon our results from the previous fMRI experiment, we had participants breathe continuously throughout this experiment, with no sniffing conditions; this significantly increased statistical power by effectively doubling the number of trials we could obtain from the same amount of sweat.
In addition to the increased statistical power by grouping shRNAs according to the functional category of their target genes, this method also drastically reduces the problem of off-target effects, as it is unlikely that multiple shRNAs have a similar off-target effect in a specific GO group.
By collapsing these health outcomes, we increased statistical power and obtained more stable estimates of risk at the cost of some specificity of the outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com