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As expected, saline-treated animals rapidly worsened renal function after I/R, as attested by increased serum levels of creatinine.
The functional deterioration of the liver, which is also evidenced by increased serum levels of bilirubin, occurs in the absence of detectable apoptosis.
These effects were accompanied by increased serum levels of glucagon-like peptide 1 (GLP-1), adiponectin and Tregs.
Autoimmune thyroiditis was defined by increased serum levels of at least one thyroid autoantibody or diagnostic FNA findings, or both.
Human aging is accompanied by increased serum levels of pro-inflammatory cytokines suggestive of chronic low-grade inflammation.
Acute and severe illness is accompanied by increased serum levels of adrenocorticotrophic hormone (ACTH) and cortisol [ 1- 21].
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The reduction of serum 1,25(OH)2D levels may result from a significant decrease in renal mRNA level for 25-hydroxyvitamin D-1a-hydroxylase (1a-OHase) and a simultaneous elevation of 24-hydroxylase mRNA, induced by increased serum level of FGF23.
Regarding the repair actions by MSCs, Saha et al. reported that MSCs could protect irradiated intestine by increasing serum levels of R-spondin1, KGF, IL-10 and PGE2, which function as effectors for promoting proliferation and inhibiting both apoptosis and inflammation within irradiated intestine.
This process is not affected by the increased serum levels of advanced glycation end-products (AGE) occurring in T2DM [ 15].
26 Moreover, the upregulation of ribosomal proteins by LNA-antimiR-214 might explain the improved protein synthesis and liver function, as demonstrated by the increased serum levels of albumin (Fig. 5).
In addition, recent reports demonstrated that HMGA1 functions as a mediator of the development of sepsis, as evidenced by its increased serum levels in patients with septic shock [ 38].
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