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The applied stress increased circulating corticosterone levels as assessed immediately after the retention test, indicating that stress-induced impairment of memory retrieval is mediated, in part, by increased plasma levels of glucocorticoids.
The dramatic reduction in hepatic SR-BI by ablation of the PDZK1 gene in Paigen diet-fed apoE KO mice was accompanied by increased plasma levels of total cholesterol (33%), unesterified cholesterol (49%), and phospholipids (36%) as well as an increase in the unesterified to total cholesterol ratio (14%) and total body weight (13%) (Table 1).
This is further evidenced by increased plasma levels of ADMA in patients with CKD, which are linked to both the development and the progression of CKD (Ravani et al. 2005; Fliser et al. 2005; Hanai et al. 2009).
T2DM can alter the pharmacokinetics of some drugs due to e.g. glycosylation of plasma proteins or displacement by increased plasma levels of free fatty acids, or through deteriorated kidney function [ 25] and also the activity of cytochrome P450 [ 26].
Familial Hypercholesterolaemia (FH) in its classical form is an autosomal dominant disorder, characterised by increased plasma levels of low-density-lipoprotein-cholesterol (LDL-C) and total cholesterol (TC) from birth and premature cardiovascular events.
In addition, the inhibition of fibrinolytic activity by increased plasma levels of plasminogen activator inhibitor type 1 (PAI-1) results in a inadequate removal of fibrin contributing to thrombosis in small and medium sized vessels [ 14].
Similar(46)
Red and white wine contain sulfites, tannins, phenols, and other compounds that are thought to cause hangover headache by increasing plasma levels of serotonin and histamine [26], [27], [28].
45 Inflammatory conditions were also observed in patients with erectile dysfunction, as shown by increasing plasma levels of TNF-α.
An accelerated methionine metabolism through the S-adenosylmethionine cycle in LSFC patients is, however, suggested by the increased plasma levels of creatine, which may reflect a low intracellular energy status (Shaham et al., 2010).
In Swiss albino mice, CMS impaired memory in object recognition test and object location test was accompanied by the increased plasma levels of IL-1 β, IL-6, and TNF- α, as well as the enhanced plasma levels of corticosterone, corticotrophin-releasing hormone, and ACTH [ 93].
79– 81 In preclinical studies, tesamorelin was found to be resistant to deactivation by DPP4, and markedly increased plasma levels of GH and IGF-1 after once daily dosing.
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by increased literacy levels
by increased plasma concentrations
by increased PKCδ levels
by increased stress levels
by increased fiber levels
by increased ERα levels
by increased expression levels
by increased plasma triglycerides
by increased COHb levels
by increased estrogen levels
by increased plasma metabolites
by decreased plasma levels
by increased sulfotransferase levels
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