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Studies of 2CP antisense lines demonstrated that decreased 2CP activity can be compensated by increased induction of APx gene expression [ 80].
Statins restore corticosteroid sensitivity in patients with asthma[ 14, 15], possibly by restoring HDAC activity[ 16] or by increased induction of indoleamine 2, 3-dioxygense resulting in increased secretion of the anti-inflammatory cytokine IL-10[ 15].
In fracture repair, TP508 has been shown to promote angiogenesis and enhance bone strength formation by increased induction of early growth factors and inflammatory mediators [ 19]. p-15 (Pepgen™) is an FDA-approved, tissue-engineered product that contains anorganic bone mineral (ABM) scaffold and is coated with an active peptide sequence.
Moreover, it indicated that NK cells may contribute to differentiation and resistance of hMSCs by increased induction of key resistance factors such as B7H1.
This is accompanied by increased induction of the HIF-1α target genes GLUT1 and phosphoglycerate kinase (PGK).
As shown in Figures 3D and S3B (lower), reprogramming of fibroblasts was also significantly enhanced following fusion with S/G2- and G2-enriched mESCs, as indicated by increased induction of human OCT4, NANOG, and CRIPTO transcripts.
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Further investigations were performed on the breast cancer cell lines T-47D, MDA-MB-231 and MCF7, and PC-3 prostate cancer cells to determine whether the increased effect of PENAO by DCA was due to increased induction of apoptosis.
Since SSc fibroblasts have an increased induction of TLR3 by IFNα2 compared with control fibroblasts, we sought to determine whether IFNα2 induction of TLR3 expression was increased in myofibroblasts.
The reduced methylation of intron 7 CpGs leads to increased induction of FKBP5 by glucocorticoid receptor activation, especially in risk allele carriers, representing an enhancement of the ultra-short feedback loop leading to increased glucocorticoid receptor resistance.
The higher abundance of Staphylococcus phage in CF is consistent with the increased induction of Staphylococcus prophage by antibiotics in CF individuals, as shown by previous studies [31].
LGALS1 has been shown to be involved in many other functions in Table 1, also plays a role in lipid metabolism, by increasing the induction of levels of phosphatidylserine as well as the mobilization of phosphatidylserine [ 46].
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