Sentence examples for by increased generation of from inspiring English sources

Therefore the induction of 20-HETE must be regulated at a step proximal to CYP4A expression and is likely due to increases in substrate delivery by increased generation of AA via cPLA2 activity or at the re-acylation of AA into membrane phospholipids as previously described [44].

In the 6-OHDA model, the neurotoxin acts selectively on nigrostriatal neurons because it is substrate of the reuptake transporter, and induces cell death by increased generation of free radicals due to autoxidation.

One mechanism proposed frequently is an increase in oxidative DNA lesions attributable to metal exposure, mediated by increased generation of highly reactive oxygen species (ROS) (Dally and Hartwig 1997; Kasprzak 1991; Kasprzak et al. 1997).

Previous reports have suggested that oxidative stress induced by increased generation of ROS is involved in the activation of NF-κB [ 12, 41].

Reduction of oxygen delivery and oxygen consumption to below a critical level produces ischemic metabolic insufficiency followed by increased generation of lactate [ 1- 4].

It is reversibly formed and secreted in the metabolism and can also be used as an effective neurotoxin possibly mediated by increased generation of free radicals or by calcium influx through NMDA receptor channels [ 15].

Combination of these two agents resulted in increased autophagy that was dependent on expression of ceramide synthase 6, with HDACIs enhancing MDA-7/IL-24 toxicity by increasing generation of ROS and Ca2+.

Diabetes is usually recognized as the vascular disease characterized by vasoregulation change, increased generation of reactive oxygen intermediates, inflammatory activation, and altered barrier function.

After exposure of these cells to asbestos, we demonstrated by fluorescence methodology a significantly increased generation of SOD with ferrireductive capacity.

Disseminated intravascular coagulation (DIC) is characterized by systemic fibrin formation, resulting from increased generation of thrombin, simultaneous suppression of physiological anticoagulants, and impaired fibrinolysis [ 3].

Because p25 preferentially distributes in the nucleus, we confirmed the increased generation of p25 by assessing its protein levels in the nuclear fraction of IGF-1-treated neurons (Fig. 2A).