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Examples from studies in vitro and in vivo include increased production of neuro-transmitters, increased number of nerves that produce specific neuropeptides, and increased neurotransmitter release from nerve terminals mediated by increased expression and function of the vanilloid receptor TRPV1 (the capsaicin receptor).
This ADMA decrease was accompanied by increased expression and activity of DDAH-1, which converts ADMA into citrulline (Fig. 6B).
Structurally, Wnt3a induced a spindle-shaped morphology characterized by increased expression and incorporation of smooth muscle α-actin into stress fibres.
This is the first demonstration that prolonged (24 h) of mechanical ventilation causes cell cycle arrest in newborn rat lungs; the arrest occurs in G1 and is caused by increased expression and nuclear localization of Cdk inhibitor proteins (p27Kip1, p57Kip2) from the Kip family.
Non-muscle invasive (NMI) bladder cancer is characterised by increased expression and activating mutations of FGFR3.
Sepsis or endotoxemia induces systemic inflammatory responses manifested by increased expression and release of proinflammatory cytokines, chemokines and adhesion molecules.
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Of note, we show that overexpression of FOXM1 induced a cell phenotype characterized by branching, extended chains of cells and cellular protrusions distinctive of a migratory phenotype and characterized by increased expression of CDC42 and RhoB and higher invasiveness.
Radiation-resistant IRR cells also revealed resistance to cisplatin accompanied by increased expression, activity and trend towards nuclear translocation of Rac1 protein.
HepG2 cells were shown to respond to hydro-dynamic shear stress by transient increase in AhR-mediated CYP1A1 activity [ 17, 18], and by increased expression of CYP3A4 and UGT2B7 [ 20].
Conversely, increased p53 activity in mice through extra transgenic copies of the ARF1 and p53 genes is accompanied by increased expression of Sesn1/2 and can delay aging and age-associated disorders and reduce ROS accumulation (Matheu et al, 2007).
In contrast, CD1a and HLA-DR are expressed on immature DCs, and maturation is revealed by increased expression of CD83, and the costimulatory molecules CD80 and CD86.
More suggestions(15)
by transgenic expression and
by increased competition and
by increased hospitalization and
by increased stability and
by mRNA expression and
by increased vigilance and
by increased migration and
by increased affluence and
by increased glycolysis and
by increased prevalence and
by low expression and
by increased openness and
by increased infertility and
by increased glycolytic and
by increased urbanization and
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