Sentence examples for by increased affinity for from inspiring English sources

Agonist-induced heterodimerization was accompanied by increased affinity for dopamine and augmented hD2R signalling as well as prolonged hSSTR2 internalization.

To investigate whether the increased potency of SII Ang II for the mutants D74N, DRY/AAY and N298A was caused by increased affinity for SII Ang II, we studied SII Ang II affinity by heterologous competition binding using tracer amounts of 3H-Ang II and unlabeled SII Ang II.

These possibilities could be facilitated by increased affinity of DNA MTases for hemimethylated substrates in comparison with non-methylated ones, unlike their REase counterparts.

The interaction of eIF4G with both eIF4E and PABP1 physically brings the 5' and 3' ends of the mRNA close together, stimulating translation initiation by increasing affinity of eIF4E for the 5'-cap.

In contrast, the receptor mutant shows robust increased potency for SII Ang II in the β-arrestin2 recruitment assay, which is likely explained by its increased affinity for SII Ang II, but could also suggest a bias towards β-arrestin-dependent signaling, as discussed below.

These results indicate that there is a positive cooperative interaction between ligand molecules and that once one ligand is bound by CTB, there is an increased affinity for CTB to bind to the neighboring ligand molecules.

Increased affinity for lipid by LNCaP cells in plasma presents a unique opportunity for its detection.

They screened ~1000 variants and demonstrated that L234Y/L235Q/G236W/S239M/H268D/D270E/S298A changes in one Fc domain and D270E/K326D/A330M/K334E changes in the other increased affinity for FcγRIIIa F158 by more than 2000-fold and FcγRIIIa V158 by more than 1000-fold (Mimoto et al., 2013a).

These data show that the increased affinity for CD8 afforded by the Q115E substitution in HLA-A2 extends the mean duration of the TCR/pMHCI interaction by only <2%99.

The CBM may disrupt hydrogen bonding between cellulose chains, or the increased affinity for cellulose provided by the CBM may overcome the energetic barrier to deform the cellulose chains as needed to allow the CD to penetrate into the film.

By increasing hydrophobicity, as confirmed by 1,8-ANS-fluorescence analysis, these changes most likely contribute to the increased affinity for Hsp70 binding.