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In some cases this is caused by incomplete understanding of the geomorphological processes influencing the different proxies used.
The use of graptolites as indicators of broader palaeogeographic and palaeoceanographic settings shows promise but, in practice, is still hindered by incomplete understanding of the various factors that controlled the distribution of graptoloids within the early Palaeozoic seas.
However, optimal use of these viruses as vectors for vaccine and other purposes is limited by incomplete understanding of their replication pathways and associated constraints on inserted foreign genes.
It can be stated more generally that the development of a versatile and comprehensive approach to reduce stable bacterial adhesion to surfaces has been limited by incomplete understanding of the regulating physicochemical material properties and factors involved in the substrate microbe interactions.
This could either be explained by incomplete understanding of the questions, or by the use of different underlying motives for the two different assignments.
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However, optimization of such a strategy, and hence clinical translation, is constrained by an incomplete understanding of mechanisms by which ultrasound-induced microbubble vibrations disrupt blood clots.
The development of these treatment strategies, however, has been hindered by the incomplete understanding of the human nucleus pulposus phenotype and by an inaccurate interpretation and translation of animal to human research.
Cell-based therapy for fatal liver disease is limited by an incomplete understanding of cell-cell interactions.
The development of successful regenerative therapies for VML has been hindered by an incomplete understanding of the molecular phenomena driving and mediating injury repair.
Attempts to identify a common pathogenic process underlying PMD have been complicated by an incomplete understanding of PLP1 dysfunction and limited access to primary human oligodendrocytes.
Thus, GWAS have been labeled as a "hypothesis-free" or "agnostic" approach, overcoming the obstacles imposed by the incomplete understanding of disease pathophysiology.
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by mathematical understanding of
by incomplete fusion of
by incomplete deprotonation of
by incomplete ordering of
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