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Non-equilibrium conditions were obtained by including all data points in the linear regression (Figure 7). Figure 6 A Spearman correlation plot depicting the [ 18 F]FCho influx determined under equilibrium and non-equilibrium conditions.
The POC example contains minimum information about the drug effect, involving only one active treatment arm and placebo, nevertheless by including all data available (i.e., repeated measurements) the pharmacometric approach results in a several fold reduction in study size when addressing the question of POC.
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We created multiple subsets from the original data by including all the 40 admixed New World individuals and a variable number (x) of unmixed individuals from the European and African populations (with the same number from each population).
However, the linear mixed model handles any degree of imbalance in data by including all available data [ 61].
Furthermore, multilevel modelling minimizes the loss of data through dropout by including all available data from participants in the analyses.
We performed intention-to-treat analyses by including all outcome data available in the article, irrespective of whether the participants completed the trial or not.
Confounding by HLA-DRB1 risk alleles was controlled by analysis of the subgroup negative for known HLA-DRB1 risk alleles and by logistic regression including all data.
Secondary analysis included comparisons of each of the vaccine formulations (RTS,S/AS01A and RTS,S/AS02B) versus control as well as an analysis taking into account mixed alleles by including all available sequence data (data not shown; analysis did not alter results as there were few such infections in our dataset).
Furthermore, trustworthiness was achieved by compiling, documenting, and including all data during the analysis process.
It also addresses securing personal information, including all data "collected by the electronic systems that are built into motor vehicles," against unauthorized access.
A modified intention-to-treat analysis was performed, including all data provided by the participants randomised.
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