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TADS was specifically designed as a comprehensive effectiveness study, able to answer clinically meaningful questions by including a broad and representative sample of depressed teens, delivering treatment at both tertiary medical centers and community clinics, and assessing functional as well as symptomatic outcomes.
We attempted to elaborate on previous review articles by including a broad spectrum of outcome measures (ie, cognition, function, behavior, and global assessment), and emphasizing comparative evidence.
We therefore began by including a broad range of constructs considered potentially important, while aiming to include at least three questions per construct.
We sought to elaborate on previous reviews articles by including a broad spectrum of outcome measures, and to determine whether these drugs have different degrees of efficacy on psychiatric symptoms and cognitive functions of dementia.
By including a broad range of health problems representative for general practice, we aimed to increase the chance to detect as many different context factors as possible, including the content of the problem.
However, it is believed that by including a broad sample of participants, by intentionally not limiting participants in their definition of workplace learning and through framing probing questions in different ways, that data were not limited by individual interpretations of workplace learning.
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Increased sample size could have been achieved by including a broader sample of ophthalmologists in the study, but this would have potentially compromised our goal of eliciting opinions from uveitis specialists with extensive experience with immunomodulatory therapy.
Nevertheless, future studies may be able to draw stronger inferences by including a broader array of dependence measures or assessing dependence prior to a quit attempt.
During the latter stages of our review process, a systematic review on a similar topic was published, however it differs from ours, having restricted studies to RCTs thus only including three studies.[ 27] By including a broader range of study types, we have been able to provide a useful summary for clinicians of the current evidence for a variety of interventions.
By including a broader evidence base, we are able to offer a more comprehensive perspective on the functioning of different mechanisms in complex health systems, particularly in terms of the interactions between the different bureaucratic mechanisms (e.g. budgeting versus management) and the interactions between bureaucratic and external accountability mechanisms.
As highlighted by Mahlberg et al. (2013: 10): 'by including a rather broad set of independent variables, we account for heterogeneity among firms, in order to mitigate the bias that could be caused by omitted variables'.
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