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Curcumin supplementation may benefit diabetic patients by improving microvascular function and preventing cardiovascular complications.
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43 Therefore, it is possible that curcumin supplementation might be beneficial for diabetic patients by improving microvascular functions and preventing the consequences of cardiovascular complications.
Our hypothesis was that increasing MAP by increasing NE doses would improve microvascular function in patients with septic shock.
Those patients who survived demonstrated improved microvascular function during the first few days of hospitalization, while no improvement in microvascular dysfunction was seen with time in non-survivors [ 13].
In acute coronary syndromes, p38MAPK inhibition could stabilize ruptured atherosclerotic plaques, pacify active plaques, and improve microvascular function, thereby reducing infarct size and risk of subsequent cardiac events.
Microcirculatory resuscitation is an important therapeutic goal, as restoration of the macro-circulation alone fails to improve microvascular function.
In this context, treatments designed to improve microvascular function and clinical outcomes should be evaluated.
Saxagliptin improved microvascular function [ 13] and Liraglutide induced weight loss [ 14] in type II diabetes.
Moreover, anti-inflammatory therapy improves microvascular function, but does not completely restore it [ 18, 24].
▪ Future work can determine if RAS antagonism can improve microvascular function and vital organ function in clinical sepsis.
Finally, targeted treatment of the endothelium, using activated protein C, also improves microvascular function and ultimately increases survival.
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