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We identified TRPV6 as a putative target of local selection by implementing a genome scan based on two summary statistics of the sequence data (Figure S1), analogous to that performed previously [6].
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Finally, we explore the use of Solexa-Illumina shoreadsads to polish the genome draft by implementing a technique to correct 454 consensus errors.
Based on known haplotype data, HAPGEN can simulate whole genome genotype data by implementing a hidden Markov model.
The linkage group wide and genome wide significance thresholds for LOD scores were determined by implementing a bootstrapping method with 10000 permutation iterations at p = 0.01 and 0.05.
Here, we implement a genome-wide noncomplementation screen for quantitative trait alleles that affect colony color or size by using the yeast deletion collection.
For such purposes, we have also implemented a genome-alignment module.
To test our framework, we have implemented a prototype genome assembler genome assembly by maximum likelihood (GAML) that can use any combination of insert sizes with Illumina or 454 reads, as well as PacBio reads.
The first type, the R genomes, was created by computationally implementing a Fisher Yates shuffle on each S. cerevisiae chromosome (Fisher and Yates 1938; Knuth 1997), which randomly shuffles all the base pairs within individual chromosomes.
Conserved genomic elements are shared by a wide spectrum of organisms, and with the increased availability of sequenced genomes, it is now feasible to identify these elements by implementing comparative genomic analysis with highly divergent species.
Like Halvade, MegaSeq implements a whole genome analysis pipeline based on the GATK Best Practices recommendations.
Therefore they cannot be implemented on a genome for which annotation is unavailable, such as the rat genome.
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