Sentence examples for by impeding the binding from inspiring English sources

Methylation of cytosine in CpG islands is associated with transcriptional repression by impeding the binding of transcription factors to cis-DNA binding elements present in the promoter regions of genes [ 80].

In addition to the potential transcriptional repressor activity of G-quadruplex sequences themselves [ 27], it has been shown previously that G-quadruplex ligands can further suppress transcription of genes containing potential G-quadruplexes in their promoters, by impeding the binding of proteins needed for initiation of transcriptional activity on DNA [ 50, 51].

EPS may also contribute to the antimicrobial resistance properties of biofilms by impeding the mass transport of antibiotics through the biofilm, probably by binding directly to these agents (42).

Likewise, by impeding the outflow of water, it could prevent the natural flushing of some oil.

The natural inhibitor of the IAPs is the protein Smac, which impedes the binding to the caspases.

This is usually due to point mutations in the BCR-ABL ATP-binding site, that impede the binding of imatinib [11].

PEGylation impeded the binding of the FL Ab to the protein, leading to the loss of fluorescence.

H3R2me2 has been found to impede the binding of effector proteins to H3K4me3 and thus to control gene expression [ 28].

It is commonly assumed that the presence of lignin in biomass restricts enzymatic hydrolysis primarily by physically impeding the accessibility of cellulase to cellulose and unproductively binding cellulase.

Firstly, by direct interference, 5MeC formation can impede the specific binding of transcription factors to recognition sites in their respective promoters [ 16].

Cytosine methylation is mostly associated with transcriptional repression, possibly by direct blocking of transcription factor binding or by recruitment of histone deacetylases, thus impeding the decondensation of higher order conformations [ 1].