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11 13 Such patients are at risk of progression to increasing flare recurrences, gouty arthropathy, destructive and deforming tophi and chronic pain, frequently accompanied by impaired physical function and poor health-related quality of life.
In this study, high disease severity indicated by impaired physical function (high BASMI and BASFI levels) and high CRP levels appeared to be strongly associated with low BMD AS within 8 years of onset.
Especially men at a relatively young age with high disease severity (indicated by impaired physical function with high BASMI and BASFI levels) are prone to have low BMD, and there is a strong tendency for an association with the diagnosis AS and high CRP.
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We hypothesised that physical exposures throughout working life were associated with impaired physical function in midlife, measured by chair-rise performance, and that the theoretical explanation could be wear and tear or accumulation of exposures during life.
Otherwise, HFpEF populations will by conception include a larger number of non-cardiac etiologies for impaired physical function, making clinical research aimed at specific treatments for HFpEF challenging (and some would argue, impossible) [ 31, 34].
Chronic pain is a potentially disabling condition affecting one in three people through impaired physical function and quality of life.
It is unknown whether muscle wasting accounts for impaired physical function in adults on maintenance hemodialysis (MHD).
Other recent studies on HRQOL in older ICU survivors have reported impaired physical function [9, 28].
In longitudinal cohort studies, physical activity is protective of impaired physical function [6] and modifies the effect of disability on depression [7].
These factors are fecal loading, loose stools, anorectal incontinence, comorbidity, impaired physical function, and impaired cognitive function (Barrett 2002).
Impaired physical function is particularly common during the first 3 6 months after discharge.
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