Zhan et al. [ 26] in 2006 first made a molecular classification, by identifying 7 subclasses of MM.
This approach identified molecular subclasses of HCC, S1, S2 and S3 (Hoshida et al, 2009), where the subclass S1 was characterised by the activation of TGF- β and WNT pathways, EMT-like phenotype and more disseminative clinical phenotype, evidenced as more frequent early tumour recurrence.
~A multi-national research team led by Duke Medicine scientists has identified a subclass of antibodies associated with an effective immune response to an HIV vaccine.
The identification of ultrastable sites in the human methylome led us to identify a subclass of CpG islands characterized by a very stable pattern of methylation encompassing the island and flanking regions, established early in development and maintained through differentiation.
Here, we identify a subclass of endogenous retroviruses (ERVs) that engages innate immune signaling in these cells.
Unsupervised analysis identified a subclass of tumours of which the majority did not show angioinvasion or metastases (Supplementary Figure S1).
In this example we see the difficulty of identifying common subclasses and how SubMap outperforms four other approaches.
Consistent with this suggestion, a recent study in macaque ACC and lateral PFC identified two functional subclasses of a total of seven separable classes, one putative interneuron subclass and one putative pyramidal cell subclass, that showed a particular prominent phase synchronization with LFP's at theta-band frequencies51.
In our previous study using similar microarray technology, we identified two distinctive subclasses of human HCCs that are highly associated with the survival of individuals with HCC4.
In addition to classify morphological cell types by soma dendrite features, subclasses of dendritic cell types may be identified by different axonal projection patterns.
