By identifying a set of core regulatory genes, most of which are part of the immune response, that can lock a larger gene network into a stable diseased state, we found that it is the process of brain inflammation that is the most likely to play the major pathogenic role in prion disease.
Here, we provide a systematic analysis of the salm-regulated genes and gene isoforms in IFMs by mRNA-Seq and identify a core set of more than 700 fibrillar-specific gene isoforms, many of which code for sarcomeric components.
Here, we illustrate the power of data-mining of FlyAtlas data by comparing epithelial transcriptomes to identify a core set of highly-expressed genes, across the four major epithelial tissues (salivary glands, Malpighian tubules, midgut and hindgut) of both adults and larvae.
We first identified a core genome by predicting orthologs among consecutively larger numbers of the bacteria (from 2 to 17), using the INPARANOID algorithm [13] in conjunction with BLAST [14].
Here we identify a core gene set by first selecting a set of probable ortholog families and then reconstructing the organismal phylogeny for the Roseobacter clade.
In sticklebacks, recent work by Jones et al. [ 6] identified a core set of genome-wide loci that are associated with the transition from marine to freshwater habitats, shedding light on the underlying genes that are responding to and driving adaptive evolution.
Moreover, this should help identify a core mechanism conserved by the different plant species for the formation of vascular tissues, whose acquisition was a major invention during the evolution of land plants.
This review was able to provide insight in the complexity of primary care as a multidimensional system, by identifying ten core dimensions that constitute a primary care system.
This review was able to provide insight in the complexity of primary care as a multidimensional system, by identifying ten core dimensions that constitute a primary care system, on three levels.
