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It is degraded by hydrolysis (of its ester bonds), which is accelerated under low pH conditions, into harmless degradation products.
Polydioxanone is a polymer that degrades by hydrolysis of its ester bonds.
PCL is degraded by hydrolysis of its ester linkages in physiological conditions and has therefore received a great deal of attention for use as a biomaterial for sustained release drug delivery systems (Lam et al. 2008; Aberturas et al. 2011).
Its resistance is due to the ability of bacteria to express beta-lactamase, an enzyme that can inactivate the drug by hydrolysis of its beta lactamic ring [8], [9].
It involves all the chemical reactions and pathways responsible for the breakdown of a protein or peptide by hydrolysis of its peptide bonds, starting from the covalent attachment of an ubiquitin moiety, or multiple ubiquitin moieties to the protein.
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Co-injection of each of the derivatives obtained by hydrolysis of 1 with its corresponding synthetic counterpart confirmed the identity of the compounds.
This lack of effect of exogenous 2-AG alone is probably due to the ease of its degradation by enzymatic hydrolysis of its ester bond and to its rapid uptake.
This was a result of the weakened solubility of N-nap-O-MalCS in the aqueous phase caused by acid hydrolysis of its maleoyl groups [80, 81].
Industrial applications have evolved from its massive use in the production of 6-aminopenicillanic acid by hydrolysis of penicillin G or V to its use as a catalyst for the synthesis of β-lactam antibiotics from their β-lactam nuclei precursors.
Ceramide is known to give rise to rigid microdomains as soon as it is formed by hydrolysis of SMase24,43,44.
Besides, it might be prepared by hydrolysis of α-TCP (TenHuisen and Brown 1998; Durucan and Brown 2000, 2002).
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