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The biodistribution of F-ML-8 in normal mice showed a fast distribution into the whole body, which was corroborated by highest accumulation of radiotracer at 5 min after intravenous injection.
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Most importantly, the artificial cartilages molecularly resembled native cartilage as evidenced by high accumulation of cartilage-specific ECM components and upregulated expression of cartilage-critical genes.
In control tissues, low basal efflux transporter activity is indicated by high accumulation of rhodamine B, whereas high basal efflux activity is indicated by low levels of rhodamine fluorescence (because more dye is effluxed from the cells).
There was slight increase in aspartate aminotransferase after injection of SMA-THP conjugate (30 mg/kg ×2), which might be caused by high accumulation of the conjugate in liver, as revealed by the distribution study (cf. Fig. 3b).
This notion is supported further by higher accumulation of hsp90, a representative of the hsp families of proteins that are known markers of thermotolerance, in aba1-1 seedlings as compared to WT.
Immediately following CAD was the induction of the isoflavonoid branch of the pathway as reflected by higher accumulation of CHS, CHR, CHI, IFS, IOMT, and IFR transcripts 4 hrs post inoculation.
The initial swelling stage of rhizome development was accompanied by the highest accumulation of mRNAs of NnAGPL1, whereas expression of NnAGPL2 was not detected during rhizome development.
Jain et al. (1989) also reported the highest accumulation of heavy metals by Lemna minor and Bacopa from the wastewater.
Moreover, the ARA contents slightly decreased, and other fatty acids (such as C18 0 and C18 1) increased, which can likely be explained by the high accumulation of lipid droplets.
The increase in hepatic CoA during fasting was blunted in the Pank1−/− mouse, and resulted in reduced fatty acid oxidation as evidenced by abnormally high accumulation of long-chain acyl-CoAs, acyl-carnitines, and triglycerides in the form of lipid droplets.
glycinea infection as deduced by the high accumulation of CAD transcripts 2 hrs after Psg-avrB inoculation.
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