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Compared with VO2-non-responders, VO2-responders were characterized by higher lactate levels and higher ∆ContCO2/∆ContO2 and ∆PCO2/∆ContO2 ratios.
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The reduced SL and increased Freq are associated with muscle fatigue most likely brought about by high lactate levels and reduced muscle glycogen [ 63].
The lower serum pH and bicarbonate in the non-survivors may be explained by the higher lactate levels, rather than by inadequate metabolic control by citrate-CVVH and acid-base balance did not independently predict mortality.
Higher lactate levels could potentially attenuate declines in blood glucose by stimulating gluconeogenesis.
All these patients also had higher lactate levels and higher ∆PCO2/∆ContO2 and ∆ContCO2/∆ContO2 ratios.
Even at higher lactate levels, only a weak, although significant, correlation exists (Figure 3).
Our pilot study showed higher lactate levels and hematologic SOFA in SLD group.
Although the term lactic acidosis is frequently used, a significant relationship between lactate and pH only exists at higher lactate levels.
Conclusion Metformin is associated with higher lactate level whatever the kidney function.
Patients in the ischemic group presented a higher lactate level and a lower creatinine clearance.
Most tumours are characterised by low extracellular pH, glucose depletion, high lactate levels and regions with low oxygen tensions (Vaupel et al, 1989, 1992, 1998).
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