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Exposure of human immature, classical DCs to CD137 protein or CD137-expressing cells induces maturation as evidenced by higher expression of costimulatory molecules and IL-12, stronger migratory activity and a higher T cell stimulatory capacity [16] [18].
Osteogenesis was also significantly enhanced by the release of Co ions as well as BMP2, characterized by higher expression of osteogenic genes (OPN, ALP, BSP, and OCN), and OCN protein secretion.
Among other mechanisms, multidrug resistance of clinical Candida strains is often caused by higher expression of genes encoding drug efflux pumps [19] [21].
Newly primed T cells are phenotypically distinct from exhausted T cells and display less differentiated phenotype characterized by higher expression of CD62L, CD27, anti-apoptotic protein bcl-2 and cytokines such as TNF-α and IL-2.
Our results show that the microbiota have extensive effects on hepatic gene expression in mice, demonstrated by higher expression of a number of key genes in metabolic function, most notably CAR, in GF mice as compared to conventionally-raised specific pathogen-free (SPF) animals.
Higher expression of LH receptor was accompanied by higher expression of progesterone receptor.
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Within this cell subset, blockade of Notch signaling ablated a distinct population characterized by high expression of the adhesion molecule ESAM, which is expressed on endothelium and regulates neutrophil extravasation.
Tolerogenic antigen presenting cells (APC) are characterized by high expression of the inhibitory receptors ILT3 and ILT4.
In our study, however, phaC1 was not induced by high expression of phaD gene in wild type of P. putida KT2440 under nitrogen limiting conditions.
At disease end-stage, microglia were characterized by high expression of galectin-3, osteopontin and VEGF, and concomitant downregulated expression of TNFα, IL-6, BDNF and arginase-1.
After expansion, CD127neg populations retained a high Treg purity, as evidenced by high expression of CD25 and FoxP3 (Figure 5B).
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