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Substantial morbidity associated with OM is further exacerbated by high frequency of recurrent infections leading to chronic suppurative otitis media (CSOM).
Environmental turbulence refers to unpredictable change in an industry (see e.g. Melville et al. 2007) induced by high frequency of firm entries and exits as well as high degrees of structural instability (Mithas et al. 2013, p. 517).
Several studies showed that 2,5% of Episodic Migraines (EM) can evolve in Chronic Migraine (CM), characterized by high frequency of attacks (≥ 15days/month for more than 3 months with at least 8 attacks having the features of migraine headache) [2].
Chromosomal aberrations in osteosarcoma are highly complex and characterized by high frequency of amplifications.
On the other hand, our cohort is characterised by high frequency of polysomy and EGFR gene amplification.
Epithelial ovarian carcinoma is characterized by high frequency of recurrence (70% of patients) and carboplatin resistance acquisition.
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In both tunicate taxa, the mRNAs were characterized by high frequencies of single nucleotide polymorphisms (SNPs, ca. 3 SNPs/100 base pairs).
Screening for NRPS by high frequencies of PCR amplification was performed and it was available in 32.5 % of the tested isolates.
Therefore, normal development of the nervous system is jeopardized as reflected by high frequencies of developmental errors, reduced brain size and impaired cognitive abilities in humans.
In all cases, strong primary immune responses were observed to the model antigens as judged by high frequencies of CD4+ CD45RO+ T cells in the stimulated cultures.
In Brazil, subtype B infections are characterized by high frequencies of viruses with the unusual GWGR motif in the V3 loop of the env gene [10], [14], [15], [16], [17].
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