Within this cell subset, blockade of Notch signaling ablated a distinct population characterized by high expression of the adhesion molecule ESAM, which is expressed on endothelium and regulates neutrophil extravasation.
Tolerogenic antigen presenting cells (APC) are characterized by high expression of the inhibitory receptors ILT3 and ILT4.
The methane-oxidation pathway, indicated by high expression of two signature enzymes of methanotrophy (that is, methane monooxygenase and methanol dehydrogenase)11, fuels the host symbiont relationship ( Supplementary Fig. 28).
In contrast, donor CD4 T cells from unconditioned mice exhibited a tolerized phenotype, characterized by high expression of PD1 and Foxp3, low level of CD40L, and inability to produce proinflammatory cytokines.
At disease end-stage, microglia were characterized by high expression of galectin-3, osteopontin and VEGF, and concomitant downregulated expression of TNFα, IL-6, BDNF and arginase-1.
In our study, however, phaC1 was not induced by high expression of phaD gene in wild type of P. putida KT2440 under nitrogen limiting conditions.
After expansion, CD127neg populations retained a high Treg purity, as evidenced by high expression of CD25 and FoxP3 (Figure 5B).
Those tumours with HF differentiation were characterised by high expression of both nuclear VDR and nuclear β-catenin, particularly within the aberrant follicles (Figure 5D).
Purity of isolated monocytes was characterized by high expression of CD14 (>96% positive cells) and absent expression of CD1a and DC-SIGN.
Those OT-1 CD8+ T cells that were stimulated with an amount of antigen greater then about 0.1 nM (10−4 µg/ml) showed active proliferation, as identified by high expression of the active cell cycle marker Ki67 (Fig. 1A).
Altered expression of Collagen I and II may also indicate a decrease in chondrocyte differentiation, which is hallmarked by high expression of collagen II and low expression of collagen I.
