Using cluster analysis, we identified 91 patients (56%) with a strong inflammatory signature, characterized by heightened expression of genes specifically expressed in CD3+ T-cells, CD4+ T-cells, CD8+ T-cells, macrophages, dendritic cells, monocytes, neutrophils, NK cells and B cells.
Our studies of mouse PCT suggest that heightened expression of EEF1A2 might contribute to transformation by promoting cell cycle progression and inhibiting apoptosis.
For example, research by Spears and his colleagues showed that group polarization, or the heightened expression of attitudes consonant with in-group prototypical norms, occurs under anonymous CMC conditions.
The inhibition of gluconeogenesis by VA extract administration was also clearly demonstrated in the present study as heightened expression of the G6Pase, F16BP and PEPCK genes, the key regulatory enzymes of gluconeogenesis.
Proteomic analyses identified vinculin as a critical factor in explaining increased adhesion and impaired migration, and transcriptomic analyses revealed a type I interferon response attributed to heightened expression of the endogenous retrovirus HERV-K; in fact, the phenotype of the neutrophil related to heightened elastase and vinculin expression can also be attributed to HERV-K.
This was one of Turner's finest performances, and by that I do not intend to discredit the authenticity of her message; it is my belief that great theater (all great art really) is a heightened expression of truth.
This is then followed by a phase in which, during the course of tissue repair, signaling pathways are reestablished through the heightened expression of novel hemi-channels related to gap junctions formation (innexins), synapsin, ReN3, voltage-gated Na channels isoform [3], [21], [31], [32].
Several tumor types show heightened expression of LSD1 (Amente et al. 2013), suggesting that it may function as an oncogene.
