Sentence examples for by haplotype analysis from inspiring English sources
Finally, the major QTL alleles identified by any map-based strategy must be introgressed into preferable genetic backgrounds selected by haplotype analysis (Fig. 2).
This was confirmed by haplotype analysis.
By haplotype analysis of the pedigree, we confirmed that EDA is our best candidate gene.
By haplotype analysis of the pedigree of Family A (Fig. 3A), the affected locus was confined to the region between DXS1039 and DXS8064.
First, by haplotype analysis and genotyping of the 63 RI strains at the Cdh23753A/G polymorphism we identified three RI strains (LXS19, LXS22, and LXS76) with recombinations that place Snhl1 close to marker rs3682060, located 3.7 Mb proximal to Cdh23.
Specifically, three positive LOD scores were generated for chromosome 1, which correspond to a shared region (LO D= 0.785) and two regions known to be excluded by haplotype analysis (LO D= 0.557 & 0.76) (Figure 3).
Similarly, the psoriasis study analyzed a region previously identified by linkage in sibling pairs, and by thorough haplotype analysis narrowed it down to a single polymorphism (having excluded the remaining nine that showed association out of hundreds studied) that also disrupted a binding site for RUNX1 [ 4].
More than half of the suggestive QTL that were identified were confirmed by the haplotype analysis and many of them also by previous findings.
The QTL identified in D on SSC 12 that regulates the level of androstenone was also identified in Y and by a single SNP in L. All suggestive QTL were confirmed by the haplotype analysis.
Highly significant associations between GBSSI and DEC and PGWC were identified respectively in five and four environments by the haplotype analysis (Table 4).
The 4th primer pair confirmed the presence of the correct SNPs determined by the haplotype analysis, but gave ambiguous results, with more than 2 different haplotype sequences appearing, suggesting the region was either a repetitive sequence or that there were technical problems with the amplification of this region.
