There is increasing evidence that the glycolytic processing of glucose is affected by trauma.
Pathological activation of PARP has been shown to decrease cytosolic NAD+ pools, to inhibit glycolytic processing of glucose and to decrease ATP production (Cipriani et al., 2005; Alano et al., 2010).
Meanwhile, PPP involves the biosynthesis of glycolytic intermediates such as fructose-6-phosphate and glyceraldehyde-3-phosphate, which are normally recycled by glycolytic process.
Sodium-coupled uptake of glutamate by astrocytes and the ensuing activation of the Na+/K+-ATPase may trigger glucose uptake and glycolytic processing (Fox et al., 1988, Magistretti, 2006), the latter process providing energy in the form of ATP to fuel glutamate uptake (Schousboe et al., 2011).
We have postulated that hypothalamic glial cells, also known as tanycytes, produce lactate by glycolytic metabolism of glucose.
Nevertheless, both C. ulcerans strains are probably able to interact with the mammalian host by glycolytic modulation of host glycoproteins.
This analysis identified genes specifically regulated by the HER2 oncogene, including VAMP8 and PHGDH, which have known functions in glucose uptake and processing of glycolytic intermediates, respectively.
RNaseY (YmdA) has been described as an essential RNase involved in processing of glycolytic mRNA, degradation of rpsO mRNA.
The accumulation of glycolytic intermediates caused by glycolytic inhibition channels glucose flux into the PPP.
This set of reactions, directly fuelled by glycolytic nutrients, is efficiently shunted by the pentose phosphate pathway.
