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Chi, J.-T. et al. Endothelial cell diversity revealed by global expression profiling.
Although it is not easy to distinguish the primary or secondary target genes by global expression profiling alone, the meta-analysis of the combined data sets of global ChIP assays and global expression profiling were able to dissect the downstream gene regulatory network of Oct3/4 as summarized in Figure 3 and 4 (see a complete list in Supplemental Table S8).
Our results demonstrate the feasibility of utilizing biomarkers discovered by global expression profiling analyses for the detection and diagnosis of OTSCC.
We demonstrated that C2mE-related transgenic mice show significant similarity to intestinal-type gastric cancer when analyzed by global expression profiling.
These functional assays serve to test and confirm the consequences of mTOR activation predicted by global expression profiling of a previous independent set of BPA-exposed HRBECs (24).
The present study indicated that human intestinal-type gastric cancers exhibited significant similarity to C2mE-related mice, especially to K19-Wnt1/C2mE K19-Wnt1/C2mEl expression profiling.
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Clusters generated by global expression profiles partitioned samples in well-distinguished subgroups that overlapped with clusters obtained using "biologic scores" (cytohistologic variables) and differed from clusters based on "technical scores" (RNA/complementary RNA/microarray quality).
The prediction of similar tumor type by global expression profile is consistent with the phenotypes of the transgenic mice.
To identify genes involved in fibroid development by performing global expression profiling on tissues of normal myometrium and uterine leiomyoma origin using Affymetrix HG-U133A GeneChip® microarrays.
Firstly, the authors identified four clearly distinct molecular synovial phenotypes by using global expression profiling.
As such, validation of global expression profiling results by independent methods, such as real-time polymerase chain reaction (PCR), Northern/Western blotting and immunohistochemical methods, is crucial.
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