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In 20 of 43 patients (47%), losses of 12p13 could be identified by genomic profiling, of those 13 small interstitial deletions (see Additional file 1: Table S1).
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We present, both by genomic profiling and screening of a defined drug library, that the principal mean to activate p53 pathway is related to interference with DNA topology, likely by DNA intercalation.
To establish the relevance of these CNV, we compared the frequency of deletions involving NRXN1-α exons in our Children's Hospital Boston population, in whom CGH testing was considered to be clinically indicated, to the frequency of similar deletions detected by array genomic profiling of equivalent resolution in normal populations.
In summary, in 20 of 43 patients (47%), losses of 12p13 could be identified by genomic profiling encompassing the ETV6 and CDKN1B genes.
In keeping with this finding is more recent research comparing molecular details of cell lines to real tumors by genomic profiling [157].
Samples were selected for low amounts of tumor infiltrating lymphocytes (TILs) by mRNA profiling because TILs have detrimental effects on genomic profiling of tumor material [ 18].
Genomic profiling of p300/CBP recruitment to DNA sequences has been analyzed by several groups using chromatin immunoprecipitation.
However, genomic profiling of papillary thyroid cancer (PTC) cases from Taiwan has not been attempted previously.
A scenario that comes to mind is one where a person at elevated risk of heart disease (determined by genomic profile and/or physical and lifestyle condition) has a sensor implanted in the tip of their finger.
By genomic profiles, luminal cell lines shared features characteristic of luminal-B tumors, including certain subtype-specific CNAs and overall higher levels of DNA amplification.
The first had known familial risk of heart disease, which was borne out by his genomic profile of both common variant and rare deleterious variant-associated risk for coronary artery disease (CAD) [ 15].
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