Functions of eight of these regulators were predicted by using only the genomic context analysis.
For one of those cases, a covalent docking prediction, confirmed by empirical screening, and combined with genomic context analysis, suggested the identity of the enzyme that catalyzes the orphan phosphatase reaction in the riboflavin biosynthetic pathway of Bacteroides.
Using the most sensitive methods available to predict function, we reanalyzed these tdCOGs by using a remote sequence similarity search, and genomic context analysis [94]–[94].
In an elegant and pioneering study by Kikuta et al. (2007) the neighborhood principle of genomic context analysis was used to discriminate between target and bystander genes of GRBs in fish genomes.
Genomic context analysis revealed that CTLP rearrangements frequently occurred in genomes that additionally harbored multiple copy number aberrations (CNAs).
Enault, F., Suhre, K. & Claverie, J.M. Phydbac "Gene Function Predictor": a gene annotation tool based on genomic context analysis.
The genomic context analysis revealed a putative distinct molecular machinery associated with the FtsZl1 family.
All detected RecU genes are distant from RuvAB genes based on genomic context analysis.
In principle, genomic context analysis should be applicable to non-coding sequences as well.
Genomic context analysis of mtrH homologs are listed in Table S3.
